Trends in concomitant cerebrovascular disease and coagulation disorders-related mortality in the United States, 1999-2020.

ABSTRACT:

Background

Cerebrovascular disease (CVD) remains a leading cause of death in the United States. Although the role of conventional stroke risk factors is well established, the impact of coagulation disorders-both inherited and acquired-on long-term CVD mortality remains underexplored.

Methods

We conducted a cross-sectional analysis using U.S. death certificate data from the CDC WONDER platform (1999-2020). Adults aged ≥ 25 years with CVD as the underlying cause and any coagulation disorder listed as a contributing cause were included. Age-adjusted mortality rates (AAMRs) were calculated per 100,000 population. Joinpoint regression was used to evaluate temporal trends, estimating Annual Percent Change (APC) and Average Annual Percent Change (AAPC) across subgroups.

Results<

SUBMITTER: Hassan IN 

PROVIDER: S-EPMC12487392 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature