Optimization and characterization of acute radiation-induced esophagitis in mice.

ABSTRACT:

Purpose

To optimize an animal model of acute radiation-induced esophagitis (RIE) in C57BL/6 mice and characterize the histopathological features of RIE at different stages.

Materials and methods

C57BL/6 mice were subjected to single thoracic X-ray irradiation at doses ranging from 5 to 30 Gy. Changes in body weight, daily food and water intake, and survival were monitored and compared within 2 weeks after radiation exposure. Epithelial damage to the esophagus, apoptosis, and inflammation at different times after irradiation were examined to characterize the pathological process of RIE.

Results

The incidence of acute RIE was strongly correlated with increasing radiation dose across all the experimental groups. No deaths were observed in mice that received 5 or 10 Gy of

SUBMITTER: Feng J 

PROVIDER: S-EPMC12487394 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature