Global trends and regional differences of hepatoblastoma: a systematic analysis and predictions to 2035 based on the global burden of disease study 2021.

ABSTRACT:

Background

Hepatoblastoma accounts for the majority of liver malignancies in children with a high socioeconomic burden worldwide. Comprehensive and accurate burden data assessment is crucial for health policy planning.

Materials and methods

Epidemiological data of hepatoblastoma was extracted from the Global Burden of Diseases Study 2021. The incidence, prevalence, mortality, and disability-adjusted life years (DALYs) were assessed and Joinpoint regression analysis was conducted to evaluate the time trends. Age-standardized rates (ASR) were used to compare the burden among different sociodemographic index (SDI) and GBD regions. The Bayesian age-period-cohort model was applied to predict the disease burden.

Results

In 2021, there were 4048.42 new cases (95% UI: 3252.45

SUBMITTER: Shi K 

PROVIDER: S-EPMC12487421 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature