Mesenchymal stroma drives axonogenesis and nerve-induced aggressiveness in osteosarcoma.

ABSTRACT:

Background

Osteosarcoma (OS), the most common primary bone malignancy, is a leading cause of cancer-related mortality in children and adolescents. Besides genomic abnormalities, several features of tumour microenvironment (TME), including cancer-associated mesenchymal stromal cells (MSC), have been recognized to play a key role in OS progression. The pathogenetic function of de novo innervation in TME has been extensively studied in carcinomas but is still an unexplored area of investigation in sarcomas, including OS.

Methods

We evaluated nerve infiltration in tissue samples from a small cohort of human OS (n = 5) and from canine OS (n = 11), a translational model for the human disease, by βIII-tubulin immunostaining. We then analysed nerve-stroma-tumour crosstalk using dire

SUBMITTER: Di Pompo G 

PROVIDER: S-EPMC12487423 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature