Visit-to-visit body mass index variability in relation to longitudinal cognitive changes in Chinese adults: a retrospective cohort study.

ABSTRACT:

Background

Body mass index (BMI) affects cognitive health throughout life. BMI variability has emerged as a promising indicator for tracking longitudinal changes in BMI. The association of BMI variability with cognitive impairment remains unclear.

Objective

This study investigated the relationship between BMI variability and cognitive outcomes across age groups defined by a 50-year threshold.

Methods

The current study enrolled 1474 participants (> 18 years) from the China Suboptimal Health Cohort Study (COCAS). Various metrics, including the coefficient of variation (CV), standard deviation (SD), variability independent of the mean (VIM), and average real variability (ARV), were used to measure BMI variability. The main clinical outcome was the incidence of cognitive

SUBMITTER: Guo S 

PROVIDER: S-EPMC12487511 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature