Computational modelling of the impact of anatomical changes on ECGs in left ventricular hypertrophy.

ABSTRACT: Left ventricular hypertrophy (LVH) is characterised by an increase in the mass and volume of the left ventricle, typically manifested as ventricular wall thickening and/or dilation. Due to its potential to cause severe, life-threatening complications, ongoing research continues to explore its underlying mechanisms. This study aimed to determine how wall thickening and dilation specifically impact ECG waveforms, isolating these anatomical alterations without considering potential electrophysiological changes associated with LVH - a scenario achievable only through computational modelling. To accomplish this, eccentric and concentric cardiac models - with growth levels from 10% to 100% mass increase - were generated using a kinematic growth, finite element model derived from a healthy contro

SUBMITTER: Kariman M 

PROVIDER: S-EPMC12487602 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature