GsMTx-4 inhibits the exercise pressor reflex and the muscle mechanoreflex primarily through TRPC inhibition.

ABSTRACT: Evidence suggests that Piezo 2 and TRPC6 channels play important roles in evoking the mechanical component of the exercise pressor reflex. However, the pharmacological tools used in previous studies, namely GsMTx-4 (Piezo 2) and SAR7334 (TRPC6), have potential overlapping effects. GsMTx-4, in particular, inhibits TRPC6 channels in addition to Piezo 2. Consequently, we determined in vivo the initial and combined effects of serial injection of GsMTx-4 and SAR7334 in evoking the mechanical component of the exercise pressor reflex in male and female decerebrated rats. In addition, in heterologous cells expressing Piezo 2 channels, we determined the effect of SAR7334 on the inward current evoked by membrane stretch. The exercise pressor reflex and the mechanoreflex were evoked by statically con

SUBMITTER: Ducrocq GP 

PROVIDER: S-EPMC12487608 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature