Association between viral hepatitis and depressive symptoms: National Health and Nutrition Examination Survey (NHANES) 2007-2018.

ABSTRACT:

Background

Evidence on the association between viral hepatitis, particularly hepatitis B and C, and depressive symptoms remains limited. This cross-sectional study aimed to evaluate this relationship.

Methods

We analyzed data from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018. HBV or HCV infections were identified through serological testing, and depressive symptoms were measured using the Patient Health Questionnaire-9 (PHQ-9). Weighted multivariable logistic regression models were used, with additional subgroup and interaction analyses. Additionally, viral hepatitis was categorized as never infected, previously infected, or actively infected to compare risks by infection status.

Results

Among 25,635 participants, 456 had HBV or

SUBMITTER: Yang G 

PROVIDER: S-EPMC12487628 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature