DGAT2 reduction and lipid dysregulation drive psoriasis development in keratinocyte-specific SPRY1-deficient mice.

ABSTRACT: Psoriasis is a chronic autoimmune skin disease characterized by abnormal keratinocyte proliferation and immune dysregulation. Altered lipid metabolism has been implicated in its pathogenesis, but the underlying mechanisms remain unclear. In this study, we generated a keratinocyte-specific Sprouty RTK signaling antagonist 1 (SPRY1) knockout (Spry1ΔEpi) mouse model, which exhibits psoriasis-like symptoms. Using both psoriasis patient samples and Spry1ΔEpi mice, we investigated the role of diacylglycerol acyltransferase 2 (DGAT2) in psoriasis. Our results show that DGAT2 expression was reduced and glyceride metabolism was disrupted in psoriatic lesions in both patients with psoriasis and Spry1ΔEpi mice. Lipidomic analysis revealed significant alterations in glycerides, glycerophospholipids, s

SUBMITTER: Li YY 

PROVIDER: S-EPMC12487672 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature