STING-adjuvanted outer membrane vesicle nanoparticle vaccine against Pseudomonas aeruginosa.

ABSTRACT: Multidrug-resistant (MDR) bacterial pneumonia poses a critical threat to global public health. The opportunistic Gram-negative pathogen Pseudomonas aeruginosa is a leading cause of nosocomial-associated pneumonia, and an effective vaccine could protect vulnerable populations, including the elderly, immunocompromised, and those with chronic respiratory diseases. Highly heterogeneous outer membrane vesicles (OMVs), shed from Gram-negative bacteria, are studded with immunogenic lipids, proteins, and virulence factors. To overcome limitations in OMV stability and consistency, we described what we believe to be a novel vaccine platform that combines immunogenic OMVs with precision nanotechnology - creating a bacterial cellular nanoparticle (CNP) vaccine candidate, termed Pa-STING CNP, which inc

SUBMITTER: Bjanes E 

PROVIDER: S-EPMC12487677 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature