Cobalt-Catalyzed Green Alkylations of Anilines with Tetrahydrofurans.

ABSTRACT: The use of bio-renewable resources as starting materials and reagents in synthetic chemistry is an important area for sustainable development. The use of tetrahydrofuran (THF) and 2-methyltetrahydrofuran (2-MeTHF) is reported, which can be obtained from lignocellulosic biomass, as potential alkylating agents for anilines. The developed N-alkylation process is catalyzed by the readily available cobalt salts and employs industrially available syngas as a reducing agent. The reported approach allows for the green and cost-effective production of N-alkylanilines from readily available feedstocks.

SUBMITTER: Balalaeva AI 

PROVIDER: S-EPMC12487734 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature