Harnessing Electron Donor-Acceptor Complexes to Improve the Sustainability of the Enantioselective β-Alkylation of Aromatic Enals.

ABSTRACT: A novel and sustainable method is presented for the enantioselective β-alkylation of enals using an electron donor-acceptor (EDA) complex-based strategy. β-Alkyl-γ-azo aldehydes, important intermediates in the synthesis of bioactive compounds, are typically synthesized using organocatalysis, rhodium-catalyzed hydroformylations, or radical additions. Existing photoredox radical approaches-particularly those relying on iminium ion excitation-display severe limitations, particularly related to overall catalytic sustainability. In contrast, this approach uses long wavelenght visible light-induced single electron transfer within an EDA complex formed between an electron-rich silane and an electron-poor iminium ion, enabling radical formation under very mild conditions. This strategy eliminates

SUBMITTER: Di Remigio S 

PROVIDER: S-EPMC12487751 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature