FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS-STING pathway.

ABSTRACT:

Background

Ferroptosis, a type of iron-dependent lipid peroxidation-induced neuronal death, has been strongly implicated in the initiation and progression of various neurological disorders, including neurodegenerative diseases and central nervous system (CNS) injuries. Although significant research efforts have been devoted to this area, most available therapeutic strategies remain largely ineffective due to the complex pathophysiology of these conditions. Moreover, the mechanisms underlying neuronal ferroptosis are not yet fully elucidated.

Methods

To investigate the role of FAHD1 in neuronal ferroptosis, bioinformatic analyses and cellular experiments were performed. Immunofluorescence and dot blot analyses were employed to explore the effects of FAHD1 overexpression on R-

SUBMITTER: Wang B 

PROVIDER: S-EPMC12487764 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature