Novel cuproptosis-related genes <i>C1QBP</i> and <i>PFKP</i> identified as prognostic and therapeutic targets in lung adenocarcinoma.

ABSTRACT: Excessive intracellular copper accumulation triggers cuproptosis, a novel regulated cell death process with therapeutic potential. Analyzing 566 The Cancer Genome Atlas samples alongside lung adenocarcinoma (LUAD)-specific microarray and single-cell sequencing data, we identified 109 cuproptosis-associated genes, of which C1QBP and PFKP emerged as key prognostic markers. Four-gene risk model stratified patients into high- and low-risk groups with distinct survival outcomes, where high-risk scores correlated with advanced TNM stages. Clinical validation confirmed that elevated C1QBP/PFKP expression in LUAD tissues predicted shorter progression-free survival. Functional assays demonstrated that silencing C1QBP or PFKP increased intracellular copper c

SUBMITTER: Lv Y 

PROVIDER: S-EPMC12487765 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature