Inhibition of histone deacetylase 3 in dental mesenchyme regulates the development of tooth root.

ABSTRACT: Studies on human and animal models have demonstrated a complex molecular regulatory network between the dental mesenchyme and epithelium governing tooth development. However, epigenetic regulation of tooth development is largely unexplored. This study aimed to elucidate the relationship between epigenetic modifiers and dental root development using mice deficient in histone deacetylase 3 (Hdac3) under the control of the osterix promoter (Osx-Cre/Hdac3fl/fl or Hdac3-CKOosx). We observed tooth root size and histology in Hdac3-CKOosx mice. Dental pulp progenitor cells (DPCs) were isolated from lower incisors, and calcification and gene expression were assessed. Hdac3 depletion in osterix-expressing dental pulp stem cells, including odontoblasts, caused a progressive postnatal obstruction, res

SUBMITTER: Niibe K 

PROVIDER: S-EPMC12487778 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature