Role of frustrations in cell reprogramming.

ABSTRACT: The cell fate transition is a fundamental characteristic of living organisms. By introducing external perturbations, it is possible to artificially intervene in cell fate and trigger cell reprogramming. Revealing the general principle underlying the induced phenotypic reshaping of cell populations remains a central focus in the field of cell biology. In this study, we investigate the energetic and dynamic features of induced cell phenotypic transition from differentiated somatic state to pluripotent state by constructing a Boolean genetic network model. The simulation and experimental results highlight the critical role of genetic frustration in initiating cell fate transitions, although the two ending phenotypic states are typically featured by minimal frustration. In addition, the altere

SUBMITTER: Yao Y 

PROVIDER: S-EPMC12487780 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature