Morphometric analysis of spina bifida after fetal repair shows new subtypes with associated outcomes.

ABSTRACT:

Objectives

The binary classification of spina bifida lesions as myelomeningocele (with sac) or myeloschisis (without sac) belies a spectrum of morphologies. This study aimed to characterize types of spina bifida lesion and correlate them with preoperative presentation and postoperative outcome.

Methods

This was a secondary analysis of a prospective cohort of patients referred for fetal spina bifida who underwent fetoscopic repair between 2020 and 2023 at a single center. We evaluated lesion morphology on high-resolution intraoperative images and videos to categorize lesions based on placode exposure and nerve root stretching. The reproducibility of lesion classification was assessed using the Kappa statistic (κ) to measure interrater agreement between a primary and a seconda

SUBMITTER: Mann LK 

PROVIDER: S-EPMC12488205 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature