Vertical Transmission of Gut Dysbiosis From Mothers With Gestational Diabetes to Infants.

ABSTRACT:

Background

Vertical transmission of microbes from a mother's gut to their offspring plays a crucial role in the genesis of the early life gut microbiome. Gestational Diabetes Mellitus (GDM) is the commonest metabolic disorder during pregnancy, which has adverse short- and long-term effects on both maternal and infant health. We aimed to capture the GDM-associated biosignatures in infants' gut microbiome from birth to the first 6 weeks of life.

Methods

53 GDM mother-infant dyads and 16 healthy mother-infant dyads were recruited. We performed targeted 16S rRNA gene amplicon sequencing on stool samples. Various statistical analyses were performed to understand the changes in the microbiome profile of infants and identify GDM-associated bacterial biomarkers in mothers and their

SUBMITTER: Low JM 

PROVIDER: S-EPMC12488368 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature