Comparative Genomics Reveals Conserved Ophiobolin Biosynthetic Gene Cluster and Necrotrophic Adaptation in Bipolaris oryzae.

ABSTRACT: Bipolaris oryzae, the causal agent of rice brown spot, is a necrotrophic fungus that produces phytotoxic secondary metabolites, yet its genomic basis of pathogenicity remains incompletely defined. We sequenced six South Korean B. oryzae isolates and analyzed them together with publicly available genomes from Bipolaris and related Pleosporaceae, covering 37 Bipolaris isolates across eight species. Phylogenomics based on singlecopy orthologs confirmed the monophyly of Bipolaris and resolved B. oryzae as a distinct lineage. Comparative analyses showed that B. oryzae has a moderately reduced secretome and fewer candidate pathogenicity gene families relative to B. maydis and B. sorokiniana, while retaining a conserved core enriched in carbohydrate and amino acid metabolism. We identified 48 sec

SUBMITTER: Hue Y 

PROVIDER: S-EPMC12488377 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature