Vitamin D₃ promotes white fat beige through IL-27/P38MAPK/PGC-1α pathway.

ABSTRACT:

Background

Obesity is turning into a more critical problem for public health. Vitamin D₃ (VD₃) may be strongly linked to obesity.

Objectives

The study aims to examine the influence of VD₃ on IL-27 levels and the molecular mechanism by which VD₃ affects white fat beige through the IL-27/P38MAPK/PGC-1α pathway.

Methods

Firstly, a small sample population study was conducted to compare the disparities in serum 25(OH)D₃ and IL-27 between individuals with obesity and healthy control groups. Secondly, twenty-four Wistar rats were separated into three groups: CON, HFD, and HFD + VD₃ groups. Following 7 weeks of intervention, detection of biochemical indicators in serum by enzyme-linked immunosorbent assay (ELIS

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12488405 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature