Proton beam radiation therapy vs. photon radiation therapy and the overall survival of adult and pediatric patients diagnosed with sarcoma.

ABSTRACT:

Background

The use of proton beam radiation therapy (PBT) has increased in patients diagnosed with sarcoma. However, there is a lack of information about its survival benefit in these patients.

Objective

We want to investigate the association of PBT with the overall survival (OS) of sarcoma patients.

Methods

We used the National Cancer Database and assessed the OS using multivariable Cox regression analysis adjusted for age, sex, race, education, income, insurance status, histology, comorbidity score, radiation therapy dose, chemotherapy, surgery, and year of diagnosis.

Results

Among the 117,694 patients, 3,573 (3%) received PBT. Patients receiving PBT had longer OS than those receiving photon radiation therapy (PRT) (HR: 0.73, CI: 0.68 -0.79). PBT was also ass

SUBMITTER: Amin SA 

PROVIDER: S-EPMC12488416 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature