Intergenerational metabolic toxicity of perfluorooctanesulfonic acid exposure in adult offspring rats: a multi-omics approach.

ABSTRACT:

Introduction

Perfluorooctane sulfonate (PFOS), known as a critical endocrine disruptor, was linked to potential intergenerational effect in population studies. Yet, the toxic metabolic mechanisms remain unclear, particularly at relatively low PFOS concentration.

Methods

This study investigated the metabolic impacts of early-life (pregnancy and lactation) PFOS exposure on adult Sprague-Dawley (SD) offspring rats using an integrated transcriptomics and metabolomics approach. Metabolic phenotypes, including glucose tolerance, lipids, and metabolic biomarkers were measured.

Results

Early-life exposure to 0.03 mg/kg PFOS was found to be associated with elevated fasting and 15-minute blood glucose, serum insulin, and adiponectin levels and a decrease of leptin level in dose

SUBMITTER: Yu G 

PROVIDER: S-EPMC12488417 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature