Curative response to combined targeted-immunotherapy for post-hepatectomy lymph node metastasis in sarcomatoid hepatocellular carcinoma: case report and literature review.

ABSTRACT: Sarcomatoid hepatocellular carcinoma (SHC) is an aggressive malignancy with poor therapeutic outcomes. Current evidence supports radical surgical resection as the primary treatment modality, yet it is associated with prohibitively high postoperative recurrence rates. We report the clinical course of a 66-year-old male diagnosed with SHC. A hepatic mass (4.1 × 2.7 × 4.4 cm) was incidentally detected during routine health screening. The patient underwent laparoscopic right posterior sectionectomy, with histopathological confirmation of SHC. Superior mesenteric lymphadenopathy suspicious for metastasis developed 1 month postoperatively. Prophylactic transarterial chemoembolization was initiated, followed by 6-month tyrosine kinase inhibitor (TKI) therapy, achieving disease stabilization. Howe

SUBMITTER: Liu P 

PROVIDER: S-EPMC12488422 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature