Future horizons in diabetes treatment: hypoglycemic activity of [1,2,4]triazino[2,3-<i>c</i>]quinazoline derivatives.

ABSTRACT: Type 2 diabetes mellitus (T2DM) remains a significant and multifaceted challenge for modern healthcare. This issue becomes even more pressing during times of armed conflict and the subsequent recovery period, as research indicates an increased incidence of T2DM among combat veterans, largely due to post-traumatic stress disorder. Although numerous antidiabetic drugs are currently available, achieving optimal control of hyperglycemia continues to be problematic. In this context, and as part of a focused search for biologically active substances within the class of substituted and condensed [1,2,4]triazino[2,3-c]quinazolines, we explored the hypoglycemic effects of a newly synthesized series of such compounds. The study involved 21 synthesized compounds bearing the [1,2,4]triazino[2,3

SUBMITTER: Trzhetsynskyi S 

PROVIDER: S-EPMC12488427 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature