Molecular mechanism of ultrafast transport by plasma membrane Ca²⁺-ATPases.

ABSTRACT: Tight control of intracellular Ca²⁺ levels is fundamental as they are used to control numerous signal transduction pathways¹. Plasma membrane Ca²⁺-ATPases (PMCAs) have a crucial role in this process by extruding Ca²⁺ against a steep concentration gradient from the cytosol to the extracellular space². Although new details of PMCA biology are constantly being uncovered, the structural basis of the most distinguishing features of these pumps, namely, transport rates in the kilohertz range and regulation of activity by the plasma membrane phospholipid PtdIns(4,5)P₂, has so far remained elusive. Here we present the structures of mouse PMCA2 in the presence and absence of its accessory subunit neuroplastin in eight different stage

SUBMITTER: Vinayagam D 

PROVIDER: S-EPMC12488499 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature