Licochalcone D reduces H₂O₂-induced SH-SY5Y cell neurotoxicity by regulating reactive oxygen species.

ABSTRACT: Oxidative stress, one of the primary pathogenic factors in neurodegenerative diseases, plays a key role in neuronal damage via various apoptotic mechanisms. Using natural antioxidants to counteract oxidative stress may be a useful approach to slow the progression of neurodegenerative diseases. Licochalcone D (LCD), a root extract of Glycyrrhiza inflata, has various pharmacological activities; nonetheless, its neuroprotective effects and cellular mechanisms against oxidative damage in neuronal cells remain to be elucidated. To address this, we examined the neuroprotective effects and mechanisms of LCD in H₂O₂-induced cytotoxicity and neurotoxicity in the SH-SY5Y human neuroblastoma cell line. SH-SY5Y human neuroblastoma cells were differentiated using retinoic a

SUBMITTER: Kwak AW 

PROVIDER: S-EPMC12488560 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature