Key genes associated with brain metastasis in non-small cell lung cancer: novel insights from bioinformatics analysis.

ABSTRACT:

Background

This study aims to investigate potential biomarkers associated with NSCLC-BM and elucidate their regulatory roles in critical pathways involved in cerebral metastatic dissemination.

Methods

The identified DEGs were subjected to functional enrichment analysis. PPI networks were predicted using the STRING database and visualized with Cytoscape. Hub genes were subsequently screened from the PPI network to construct a transcription TF-miRNA regulatory network. Subsequent analyses included: survival analysis, immune infiltration assessment and comprehensive mutational profiling.

Results

Among the 56 identified DEGs, 19 were upregulated while 37 were downregulated. GOntology enrichment analysis revealed significant enrichment in immune response, signaling recepto

SUBMITTER: Zhao S 

PROVIDER: S-EPMC12488587 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature