Single-cell profiling uncovers PTPRG-driven stemness in malignant plasma cells and signatures of treatment failure in multiple myeloma.

ABSTRACT:

Background

Multiple myeloma (MM) is characterized by extensive intratumoral heterogeneity and complex interactions within the bone marrow microenvironment, yet the cellular and molecular drivers of treatment resistance remain poorly defined. Protein tyrosine phosphatase receptor gamma (PTPRG) has emerged as a candidate tumor suppressor in various malignancies by antagonizing proliferative and survival signaling, but its functional and prognostic relevance in MM has not been established.

Methods

We analyzed 103,171 single-cell transcriptomes from 18 MM samples (10 optimal responders [OR] and 8 suboptimal responders [SOR] to bortezomib-melphalan-prednisone) to investigate cell-type composition, malignant plasma cell subclusters, and tumor-microenvironment crosstalk. InferCNV w

SUBMITTER: Tan J 

PROVIDER: S-EPMC12488599 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature