Intrinsic calcium resonance and its modulation: insights from computational modeling.

ABSTRACT: Hippocampal neurons generate membrane potential resonance due to specific voltage-gated ion channels, known as resonating conductances, which play crucial physiological roles. However, it is not known whether this phenomenon of resonance is limited to membrane voltage or whether it propagates through molecular signaling components such as calcium dynamics. To test this, we first utilized a single-compartment model neuron to study the oscillatory intrinsic calcium response dynamics of hippocampal model neurons, and the effects of T-type calcium channel kinetics on the voltage and calcium resonance. We found that in the presence of T-type calcium channels, our model neuron sustained a strong calcium resonance compared to voltage resonance. Unlike voltage resonance, calcium resonance frequenc

SUBMITTER: Rathour RK 

PROVIDER: S-EPMC12488614 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature