Increased IgG4 expression within tertiary lymphoid structures of esophageal cancer and implications for prognosis.

ABSTRACT:

Background

Tertiary lymphoid structures (TLS) have been observed in various tumors, including esophageal squamous cell carcinoma (ESCC), where they function as active centers of humoral immunity within the tumor microenvironment, facilitating the production of distinct immunoglobulin (Ig) subtypes with diverse effects. This study aimed to investigate the expression of TLS-associated Ig in ESCC and its prognostic significance.

Methods

A retrospective analysis was conducted on 109 ESCC cases. TLS presence was evaluated using immunohistochemistry, and the expression of Ig-positive cells was assessed. Additionally, gene expression profiles related to TLS were analyzed with gene chip data from 274 ESCC cases obtained from the GEO database.

Results

Among the 109 ESCC cases,

SUBMITTER: Su C 

PROVIDER: S-EPMC12488685 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature