Light-driven biosensor for the rapid and selective detection of hypoxia-inducible factor-prolyl hydroxylase domain inhibitors in aqueous media and saliva.

ABSTRACT: Hypoxia-inducible factor-prolyl hydroxylase domain inhibitors (HIF-PHI) are to increase the production of EPO and haemoglobin in patients with chronic kidney disease. HIF inhibitors such as Molidustat and Vadadustat are used as doping agents in racing sports. We present new sensitive and selective materials for the biosensing of Molidustat and Vadadustat in aqueous solution and saliva. Plasmonic nickel foam was synthesised using a reproducible chemical method that deposits forests of closely packed cauliflower-shaped gold nanostructures on the nickel surface. The plasmonic material showed a high enhancement factor of Raman signals (1.09 × 10⁷). Therefore, it was used as a sensor for the detection of HIF inhibitors by surface-enhanced Raman spectroscopy (SERS). A target-specific

SUBMITTER: Houston RL 

PROVIDER: S-EPMC12488750 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature