Cocktail vaccine induces immunoprotection and modulates the fecal microbiota in dogs against Echinococcus granulosus infection.

ABSTRACT: Cystic echinococcosis (CE) is a global zoonotic parasitic disease that represents a significant public health challenge. Although vaccination is considered an ideal strategy for controlling CE, no effective vaccines are currently available for dogs. Herein, bioinformatic approaches were employed to identify vaccine candidates. The selected proteins, including Echinococcus granulosus enolase (EgENO), severin (EgSev), cyclophilin (EgCyc), fatty acid-binding protein 1 (EgFABP1), calmodulin (EgCaM), and serine protease inhibitor 1 (EgSrp1), were expressed in Escherichia coli. These proteins were grouped into cocktail vaccines: rEgENO&rEgSev&rEgCyc and rEgFABP1&rEgCaM&rEgSrp1, and were combined with the Quil-A adjuvant to evaluate vaccine efficacy in beagles. After two subcutaneous immunization

SUBMITTER: Shao G 

PROVIDER: S-EPMC12488870 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature