Morphological and metabolic alterations in different stages of Alzheimer's diseases: a study using surface-based morphometry (SBM) and amide proton transfer (APT) imaging.

ABSTRACT: Early diagnosis of Alzheimer's disease (AD) remains a significant challenge due to the lack of objective biomarkers. Accurate identification of morphological and metabolic alterations during the different stages of AD is crucial for timely intervention and effective management of the disease. Surface-based morphometry (SBM) and amide proton transfer (APT) imaging are innovative techniques that offer the potential to visualize these changes in the brain. By leveraging these advanced imaging modalities, this study aims to investigate the specific alterations that occur in AD, thereby exploring potential imaging biomarkers that could facilitate early and precise diagnosis of the condition. The identification of such biomarkers is essential for improving the diagnostic accuracy and efficacy of

SUBMITTER: Zhong M 

PROVIDER: S-EPMC12488914 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature