Developmental low-dose bisphenol A exposure leads to extensive transcriptome female masculinization and male feminization later in life.

ABSTRACT:

Background

Bisphenol A (BPA) is an endocrine disruptor, and exposure to low doses in utero has been associated with the development of metabolic diseases. Previous studies have suggested that bone marrow (BM) may be particularly susceptible to BPA exposure.

Methods

Here, we investigate how developmental exposure to low levels of BPA affects the BM transcriptome and the blood metabolic profile in Fischer 344 rats later in life. We compare these effects to those observed in human metabolic syndrome (MetS) using a population-based cohort.

Results

The results show an unexpectedly extensive sex-biased effect on the BM transcriptome from a BPA dose approximately eight times lower than the recent temporary European Food Safety Authority (EFSA) human tolerable daily intake (T

SUBMITTER: Lind T 

PROVIDER: S-EPMC12488919 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature