Antinociceptive effect of Arvelexin in male mouse models.

ABSTRACT: This research evaluated the analgesic properties of Arvelexin through different models of nociception. Different concentrations of Arvelexin (50, 100, 150, and 200 µg/kg body weight) were administered to male mice, and their responses to pain were assessed using various evaluation techniques. The results were compared with those from mice receiving treatments of acetylsalicylic acid or morphine, with and without the addition of naloxone. Furthermore, to explore the impact of Arvelexin on pain modulation systems, additional tests using capsaicin and glutamate focused on its influence on vanilloid and glutamatergic pathways. The research illustrated a significant, dose-related reduction in pain during the acetic acid-induced writhing assay, with a peak decrease of 75.1% observed at 200 µg/kg

SUBMITTER: Bseiso Y 

PROVIDER: S-EPMC12488986 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature