Longitudinal changes in gut microbiota composition during endocrine therapy in hormone receptor-positive breast cancer patients.

ABSTRACT: This prospective study of 90 breast cancer patients examined gut microbiota composition relative to hormone receptor status and endocrine therapy changes. Initial analysis suggested hormone receptor-negative patients had higher Fusobacteriaceae and Fusobacterium abundance, while hormone receptor-positive patients showed Ruminiclostridium enrichment, though differences lacked statistical significance after correction. Hormone receptor-positive patients without lymph node metastasis demonstrated potentially greater microbial diversity, but associations were non-significant after multiple comparison correction. Longitudinal analysis of 52 hormone receptor-positive patients revealed the most robust finding: statistically significant Blautia increases after hormone therapy and aromatase inhibit

SUBMITTER: Tsai CH 

PROVIDER: S-EPMC12488989 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature