Effects of electroconvulsive therapy on hippocampal longitudinal axis and its association with cognitive side effects.

ABSTRACT:

Background

Electroconvulsive therapy (ECT)-mediated hippocampal volumetric increase is consistently reported, though its clinical relevance remains debated. This study evaluates if ECT-related cognitive side effects are associated with regional volumetric changes along the hippocampal longitudinal axis.

Methods

Longitudinal T1-weighted MRI scans in 435 patients (54.0 ± 15.0 years, 261 female) with major depression from the Global ECT-MRI Research Collaboration (GEMRIC) were used to measure changes in right global and longitudinal axis hippocampal subdivisions (head, body, tail) from baseline to post-treatment. Cognitive side effects were evaluated using pre-to-post treatment changes in two different verbal fluency tests available for 124 patients. Electric field modelling wa

SUBMITTER: Ousdal OT 

PROVIDER: S-EPMC12489027 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature