Reduced brain structural similarity is associated with maturation, neurobiological features, and clinical status in schizophrenia.

ABSTRACT: Schizophrenia spectrum disorders (SSD) are characterized by atypical brain maturation, including alterations in structural similarity between regions. Using structural MRI data from 195 healthy controls (HC) and 352 individuals with SSD, we construct individual Morphometric INverse Divergence (MIND) networks. Compared to HC, individuals with SSD mainly exhibit reduced structural similarity in the temporal, cingulate, and insular lobes, being more pronounced in individuals exhibiting a 'poor' clinical status (more impaired cognitive functioning and more severe symptomatology). These alterations are associated with cortical hierarchy and maturational events, locating MIND reductions in higher-order association areas that mature later. Finally, we map 46 neurobiological features onto MIND net

SUBMITTER: Garcia-San-Martin N 

PROVIDER: S-EPMC12489120 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature