Helicobacter pylori antimicrobial resistance and gene variants in Shandong Province.

ABSTRACT: The emergence of antibiotic resistance in Helicobacter pylori led to a sharp decline in eradication rates, but there are limited data regarding the prevalence and genetic mechanisms of antibiotic resistance in Shandong. This study aims to assess the prevalence and molecular mechanisms of H. pylori antibiotic resistance to commonly used antibiotics in Shandong populations. Antimicrobial susceptibility testing was performed for clarithromycin, levofloxacin, metronidazole, tetracycline, rifampicin, amoxicillin, azithromycin, and moxifloxacin using E-test method. PCR amplified resistance-associated genes for all the strains, and 32 were whole-genome sequenced. 62 H. pylori strains were obtained and the infection rate was 30.1% (62/206). No resistance to amoxicillin was observed. Two and four s

SUBMITTER: Xue Z 

PROVIDER: S-EPMC12489142 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature