Oncogenic Role and Drug Resistance Effect of CCDC6 in iCCA: Potential Strategies for Targeted Intervention.

ABSTRACT: Intrahepatic cholangiocellular carcinoma (iCCA) is a digestive neoplasm with a very poor prognosis. This study examined the role of CCDC6 in the progression of iCCA and gemcitabine resistance through bioinformatics analysis and functional assays. Database analysis showed that CCDC6 was significantly overexpressed in iCCA, with its expression positively correlating with TNM stage and lymph node metastasis. Although its value as an independent prognostic biomarker was not statistically significant in survival analysis, its expression profile suggested potential as a therapeutic target. Functional experiments demonstrated that CCDC6 knockdown inhibited iCCA cell proliferation, migration and invasion in vitro in a dose-dependent manner, while overexpression enhanced these malignant phenotypes.

SUBMITTER: Chen J 

PROVIDER: S-EPMC12489175 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature