Systematic Analysis of CA9 as a Pan-Cancer Marker for Prognosis and Immunity.

ABSTRACT:

Background

Carbonic anhydrase 9 (CA9) plays a crucial role in pH regulation and adaptation under hypoxic conditions in the tumor microenvironment. Despite its known involvement in the progression of specific cancers, a comprehensive pan-cancer examination of the prognostic value and biological implications of CA9 has not been performed. This study systematically explored the diverse roles of CA9 across multiple cancer types.

Methods

Bioinformatics methods were applied via extensive datasets from TCGA, GTEx, CPTAC, CancerSEA, and the public literature. We systematically analyzed the associations between CA9 expression profiles and various clinical parameters, prognosis, immune infiltration, immune-related genes, TMB, MSI, and tumor stemness scores. Additionally, a single-cell

SUBMITTER: Yi Q 

PROVIDER: S-EPMC12489208 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature