Surface Wipe Sampling of Hazardous Medicinal Products: A European Interlaboratory Comparison Study.

ABSTRACT: Workplace monitoring of hazardous medicinal products (HMPs) using surface wipe sampling is becoming common practice in many European hospitals and pharmacies. However, no independent quality control is available to validate wiping procedures and analytical methods. This study aimed to conduct a Europe-wide interlaboratory comparison (ILC) program to independently and blindly assess laboratory performance and variability in HMP detection. Four European laboratories participated in the study. Six HMPs-cyclophosphamide, etoposide, gemcitabine, ifosfamide, methotrexate, and paclitaxel-were prepared at four concentrations (5000, 2000, 200, and 20 ng/mL) and applied to a 400-cm² stainless-steel surface, then wiped by the coordinating body according to each laboratory's protocol. Wipe

SUBMITTER: van den Berg RB 

PROVIDER: S-EPMC12489289 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature