Association among circulating erythropoietin-producing hepatoma A2, progranulin, and kidney function in individuals with diabetes.

ABSTRACT:

Background

Erythropoietin-producing hepatoma A2 (EphA2), a receptor for progranulin (PGRN), which is a growth factor associated with metabolic disorders, is implicated in inflammation and atherosclerotic diseases. Since both EphA2 and PGRN play roles in diabetic kidney disease (DKD) and cardiovascular disease (CVD), this study examined their association with renal function and CVD markers in individuals with diabetes. In addition, the diagnostic value of EphA2 and PGRN in predicting renal impairment was evaluated.

Methods

Circulating EphA2 and PGRN levels were measured using enzyme-linked immunosorbent assay in 735 participants with diabetes. Clinical data, including biometric parameters, physiological measurements, and comorbidities, were collected for analysis.

Results<

SUBMITTER: Murakoshi M 

PROVIDER: S-EPMC12489330 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature