Bidirectional causal links between diabetes mellitus and autoimmune liver diseases: Insights from Mendelian randomization.

ABSTRACT:

Background

Diabetes, a growing global public health issue, is often associated with autoimmune liver diseases (AILD), such as autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), in both type 1 diabetes (T1DM) and type 2 diabetes (T2DM). However, the causal relationship between these conditions remains unclear.

Methods

We used two-sample bidirectional Mendelian randomization (MR) to explore causal links between AILD and diabetes. Genetic variants identified from genome-wide association studies were used as instruments. Sensitivity and multivariable analyses adjusted for potential confounders were performed to assess the robustness of findings.

Results

Genetically predicted PBC (OR 1.41, 95% CI 1.19-1.67) and PSC (OR

SUBMITTER: Kuang H 

PROVIDER: S-EPMC12489338 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature