Effect of age and sex on the urinary elimination of a single dose of mixed flavonoids: results from a single-arm intervention in healthy United Kingdom adults.

ABSTRACT:

Background

Nutrition intervention trials demonstrate that increased flavonoid intake can have clinically meaningful impacts on disease outcomes/biomarkers; however, high variability in absorption and metabolism and large heterogeneity in biochemical and physiological responses are observed. The etiology of this variability is poorly understood.

Objective

The objective of this study was to explore the relationships between sex, age, and microbiota speciation on mixed flavonoid elimination over 24 h.

Methods

Healthy males and females (n = 163) prospectively recruited on the basis of age (18-30 y or 65-77 y) and sex consumed a standardized flavonoid-rich test meal providing 640-mg cocoa/chocolate flavan-3-ols, 340-mg citrus flavanones, and 390-mg blackberry anthocyanins.

SUBMITTER: Kay CD 

PROVIDER: S-EPMC12489340 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature