Distinct Role of Dural and Leptomeningeal Macrophages in Maintaining Cerebrospinal Fluid Drainage to Meningeal Lymphatic Vessels.

ABSTRACT: Cerebrospinal fluid (CSF) drains along the perivascular space, known as the glymphatic system, to the meninges, where meningeal lymphatic vessels (MLVs) remove toxic products with excess CSF from the brain. Macrophages are widely present in the leptomeninges and dura mater of meninges. However, whether leptomeningeal and dural macrophages play the same or distinct roles in maintaining optimal CSF drainage remains unclear. Intracisterna magna injection of clodronate liposomes indicated a comprehensive depletion of leptomeningeal macrophages, a selective reduction in dural sinus-associated macrophages, a decreased density of MLVs, and disrupted CSF drainage. Macrophage depletion was associated with the infiltration of monocytes and the recovery of monocyte-derived macrophages. By day 14 afte

SUBMITTER: Lohat V 

PROVIDER: S-EPMC12489351 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature