Are adults with chronic pain more likely to develop hypertension than adults without chronic pain? A systematic review and meta-analysis.

ABSTRACT:

Background

An association between persistent pain and blood pressure is increasingly recognised but is not fully understood. In this systematic review, we aimed to establish whether chronic pain (CP) is associated with a diagnosis of hypertension (HTN).

Methods

After prospective registration (PROSPERO ID: CRD42025629486), we searched six databases from inception until January 8, 2025, for studies investigating the association between CP and HTN. Title and abstract screening, full-text review, data extraction, and risk of bias assessment were performed by two independent reviewers. Study quality assessment used the Risk of Bias In Non-randomised Studies of Exposures (ROBINS-E) tool. Meta-analysis was conducted using a random effects model.

Results

From 7973 records, we

SUBMITTER: Taylor HE 

PROVIDER: S-EPMC12489386 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature