<i>In Silico</i> Identification of Chiral Biflavonoids as Dual PI3Kα/mTOR Inhibitors.

ABSTRACT: The PI3K/AKT/mTOR pathway is crucial in regulating key processes in mammalian cells, and impairments of this pathway are associated with cell survival in several cancer types. PI3Kα is the second most mutated oncogenic protein, and its overactivation initiates a secondary signaling cascade that enhances, among others, the activity of mTOR complexes 1 and 2. Despite the importance of this pathway, there is a gap in identifying dual inhibitors targeting both PI3Kα and mTOR, which could potentially overcome the limitations of single-target therapies. In this study, advanced computational tools were employed to identify plant-derived compounds with selective or dual inhibitory potentials against PI3Kα and mTOR enzymes. Compounds were obtained from the NuBBe database, a catalogue of Brazilian n

SUBMITTER: Nunes Azevedo FF 

PROVIDER: S-EPMC12489665 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature