Pharmacokinetic Profiling and Tissue Distribution of Seven Key Saponins in Rats Following Oral Administration of Panacis Japonici Rhizoma Extracts.

ABSTRACT: The pharmacokinetics and distribution of natural compounds in living organisms are crucial to understanding their therapeutic potential and safety. In the study, ultraperformance liquid chromatography-mass spectrometry (UPLC-MS/MS) was employed to develop a method for the separation and analysis of seven saponins, namely, G-Rg₁, G-Re, G-Rb₁, G-Ro, PG-RT₁, CS-IV, and CS-IVa, in plasma and tissue samples derived from Panacis Japonici Rhizoma (PJR). Additionally, the pharmacokinetic profiles and tissue distribution characteristics of these saponins in rats were systematically investigated. Following the oral administration of 2 g/kg of PJR extracts, UPLC-MS/MS was utilized to analyze the compounds' presence in plasma and various tissues. Key findings indicate

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12489687 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature