Association of fever and infections with the subsequent risk of atopic diseases in children with genetic susceptibility for T1D: Results from the TEDDY cohort study.

ABSTRACT:

Background

The increased prevalence of atopic diseases may be due to lifestyle changes affecting our exposure to microbes. We investigated the association between infections, fever, and atopic diseases in a large international birth cohort setting.

Methods

3842 children at genetic risk for type 1 diabetes were followed prospectively for the first 10 years for the occurrence of infections and atopic diseases within The Environmental Determinants of Diabetes in the Young (TEDDY) study. A time-discrete survival analysis was carried out to evaluate the association of self-reported febrile and non-febrile infections (respiratory, gastrointestinal, other, fever alone) and the risk of subsequent atopic eczema, allergic rhinitis, asthma, and allergies.

Results

The rate of res

SUBMITTER: Palmu T 

PROVIDER: S-EPMC12489715 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature